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A clinical study was made on 52 cases who were treated for congenital syphilis at Chonnam University Medical School Hospital. Of these, 39 cases were admitted to the Pediatric Department of C.U. M.S.H. from Jan. 1971 to Dec. 1978 via the outpatient dispensary and 13 cases were born in C.U.M.S.H. from Jan. 1974 to Dec. 1978. The results are summarized as follows : 1) 8 % of the total low birth weight infants and 0.5% of the infants who weighed over 2,500gm at birth were diagnosed as congenital syphilis. 2) In sex distribution 36 were male and rest of them were female. 3) Among the low birth weight infants 70% of the congenital syphilitic patients were premature. 4) The first clinical symptom appeared within the fourth week after birth in 90.4%, within the first week in 53.9% and after the fourth week in 9.6% of the cases. 5) The most frequent clinical manifestation was hepatomegaly (79%), next in order of skin manifestation (72%), anemia (60%), splenomegaly (79%), rhinitis and snuffle (48%). 6) In V.D.R.L. test, 96% of the patients, 98%, of the mothers and 72% of the fathers revealed reactive reponse. 7) Bony changes of roentgenographic examination were detected in 47 cases(90%). 8) 16 cases of congenital syphilitic patients in low birth infants (52 cases) and 8 cases of congenital syphilitic patients who weighed over 2, 500gm at birch were died and the most common cause of death in the patients of low birth weight infants was prematurity.
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